SKU: 45639087282

Zoetis INFORCE 3® Respiratory Vaccine

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Description

Zoetis INFORCE 3® Respiratory VaccineRespiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3 the market leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young

Respiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3® the market-leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young as 3 days old, at weaning, before moving to group pens, or with cows and heifers at prefreshening.

Indications
Helps protect against respiratory disease caused by BRSV, IBR and PI3.
Available As

Vials

For use with

Beef

Dairy

How it Works

As an intranasal respiratory vaccine, INFORCE 3® causes a local immune response with viral antibodies produced in the nasal passage where BRSV, IBR and PI3 are most likely to enter the animal’s system.

INFORCE 3® is the first commercially-available intranasal respiratory vaccine to help protect against respiratory disease caused by BRSV, while also protecting against IBR and PI3, to help get cattle off to a healthier, more productive start.

INFORCE 3 has a six-month duration of immunity claim for IBR protection, and a single-nostril administration claim. Additional research also demonstrated no maternal antibody interference for IBR and BRSV.2,3

Safe for all ages, types and classes of cattle

INFORCE 3® is safe for use in all types, ages and classes of cattle. INFORCE 3 was demonstrated safe for use in very young, high-stress calves; weaned and high-stress stocker calves; and pregnant heifers and cows.

The Science Behind Effective Control

  • Intranasal administration works with the animal's immune system for fast, effective response
  • Helps prime the immune system for a memory response to subsequent vaccinations as well as disease challenges
  • Contains proprietary, temperature-sensitive IBR and PI3 strains that replicate most effectively in the upper respiratory tract
  • Stimulates interferon release for protection
  • Helps deliver a healthy start for young dairy calves

Proven Respiratory Disease Protection

  • In two different studies, all calves vaccinated with INFORCE 3 survived severe BRSV challenges in which 100% and 90% of unvaccinated controls either died or had to be humanely euthanized.4,5
  • INFORCE 3 was shown to help prevent respiratory disease caused by IBR and PI3 and reduce level and duration of viral shedding caused by IBR and PI3.6-8
  • A study comparing INFORCE 3 and TSV-2® demonstrated that vaccinating cows and heifers with INFORCE 3  prior to freshening helped support overall positive production:
    • 205 pounds more milk per cow per lactation9
    • Increased income per cow9

Directions

Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, mix well and administer 2 mL intranasally using a cannula. Place the 2-mL dose in a single nostril or place 1-mL in each nostril. 

Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization. Annual revaccination with a single dose is recommended. 

For further advice on revaccination frequency, consult your veterinarian.

PRECAUTIONS:

  1. Store at 2°-8°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

  2. Use entire contents when first opened.

  3. Sterilized syringes should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

  4. Inactivate unused contents before disposal.

  5. Do not vaccinate within 21 days before slaughter.

  6. Contains gentamicin as preservative.

  7. Fetal health risks associated with the vaccination of pregnant animals with modified live vaccines cannot be unequivocally determined during clinical trials conducted for licensure. Appropriate strategies to address the risks associated with modified live vaccine use in pregnant animals should be discussed with a veterinarian.

  8. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

References

  1. Based on number of doses and overall sales of respiratory vaccines. Animalytics Segment Data, Biologicals Therapeutic Category, Ending MAT May 2021.
  2. Mahan SM, Sobecki B, Johnson J, et al. Efficacy of Intranasal Vaccination With a Multivalent Vaccine Containing Temperature-Sensitive Modified-Live Bovine Herpesvirus Type 1 for Protection of Seronegative and Seropositive Calves Against Respiratory Disease. J Am Vet Med Assoc. 2016;248(11):1280-1286.
  3. Ellis JA, Gow SP, Mahan S, Leyh R. Duration of Immunity to Experimental Infection With Bovine Respiratory Syncytial Virus Following Intranasal Vaccination of Young Passively Immune Calves. J Am Vet Med Assoc. 2013;243(11):1602-1608.
  4. Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.
  5. Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.
  6. Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc.
  7. Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc.
  8. Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.
  9. Data on file, Study Report No. 10PETINF01, Zoetis Inc.
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Wonderful read it really helped put in perspective how we can have grace with our kids and ourselves. Not everyone was raised this way and it is so nice to find and learn how we can unlearn some of those "bad" habits and refrigerator our minds so that we have a stronger relationship and more respectful relationship with our kids and the Father.
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Michelle Patrick
Fort Morgan, US
★★★★★ 5
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Ok, so generally, I hate parenting books. I've read at least 5 well known Christian parenting books, and I'm usually either bored to tears with impractical theories that don't really work with my three strong-willed boys, or angry at the over-simplified anecdotes that also don't work with my kids. It feels like most parenting books are written by men who have fully-grown children and I struggle to relate. I've gleaned a few techniques here and there that have been helpful, but left mostly dissatisfied. I have to say that I have been pleasantly surprised by this one! I appreciate that it's written by a fellow mom who is not too far down the parenting road that she's forgotten how hard it is. And she is funny! The embarrassing story she shares about her daughter's first birthday party literally had me laughing so hard I had tears rolling down my face. That alone was worth the book for me. I'm only about halfway through right now, but it's been such a refreshing book. I love the practical ideas for sorting family rules/values, and evaluating infractions, misdemeanors and felonies. The suggested activities are practical and not overwhelming. I find myself wanting to discuss it with my husband to try some different ideas already. That is a win! And ultimately the gospel-centered approach of what it looks like to parent our children the way God parents us - with a balanced grace - is what I want to be doing.
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Reviewed in the United States on January 10, 2017
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Carnegie, US
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I really enjoyed the book a lot! I laughed and I cried, then I laughed some more. The way you wrote the book is how I would write something like this. I really appreciated how you described your real life circumstances, most I can relate to… i.e. don’t open another cereal box till the current one is empty, how you threw together Riley’s birthday party but said all-well and let God lead, and how you are a visual learner and your husband lives on an Excel sheet. LOL, so funny! I really loved how you put humor into what can be an exhausting task of parenting, we need the laugh. On a serious note, it was great that you started w/ the idea of your own heart check before you disciple your children and that the idea is to always discipline in our kids’ best interests. I also loved learning to “protect our kids LESS so we can PREPARE them more.” Our son is in 6th grade this year and boy is that an eye opener and true statement for him. Having good boundaries (rules), decipher each violation, what are his motives, and the consequences (and specific listed ones) were amazing and a huge confirmation for me as we’ve started into the pre-teen years. Thank you so much for a God-led book on parenting when it’s the hardest but most rewarding thing a person can ever do.
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