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Description
CD137 Recombinant Rabbit mAb (S-547-17)Product Specification Host Rabbit Antigen CD137 Synonyms Tumor necrosis factor receptor superfamily member 9; 4 1BB ligand receptor; T cell antigen 4 1BB; Tnfrsf9; Ila; Ly63 Immunogen Synthetic Peptide Location Cell membrane Accession P20334 Clone Number S 547 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IP Reactivity Ms, Rt Purification Protein A Concentration 0. 1 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | CD137 |
| Synonyms | Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; Tnfrsf9; Ila; Ly63 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P20334 |
| Clone Number | S-547-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IP |
| Reactivity | Ms, Rt |
| Purification | Protein A |
| Concentration | 0.1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:2000 | |
| IP | 1:25 | |
| IHC-P | 1:2000 |
Background
CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. CD137 is only expressed on the cell surface after T cell activation. When T cells are activated by Antigen Presenting Cells (APCs), CD137 becomes embedded in CD4+ and CD8+ T cells. CD137 is a costimulatory molecule functioning to stimulate T cell proliferation, dendritic cell maturation, and promotion of B cell antibody secretion. As a T cell co-stimulator, T cell receptor (TCR) and CD28 signaling causes expression of CD137 on T cell membranes. When CD137 then reacts with the CD137 ligand, it leads to CD137 upregulation. This is a form of self regulation or positive feedback cycle. When CD137 interacts with its ligand, it leads to T cell cytokine production and T cell proliferation, among other signaling pathway responses.
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