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Description
Histone H3 (acetyl K4) Recombinant Rabbit mAb (S-4365)Product Specification Host Rabbit Antigen Histone H3 (acetyl K4) Synonyms H3K4ac Location Nucleus Accession P68431 Clone Number S 4365 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample TSA treated HeLa Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 (acetyl K4) |
| Synonyms | H3K4ac |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-4365 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | TSA treated HeLa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
Histone H3 lysine 4 acetylation (H3K4ac) is a crucial epigenetic modification. It specifically refers to the acetylation of the lysine residue at the fourth position (K4) on the N-terminal tail of histone H3. This modification is primarily catalyzed by histone acetyltransferases (HATs), such as p300/CBP, and can be removed by histone deacetylases (HDACs). Functionally, H3K4ac is strongly associated with transcriptional activation. It is typically enriched at active regulatory regions, including gene promoters and enhancers. By neutralizing the positive charge on the lysine, H3K4ac weakens the interaction between histones and the negatively charged DNA, leading to a more open chromatin structure. This relaxed state facilitates the binding of transcription factors and RNA polymerase II, thereby promoting gene expression. H3K4ac often functions cooperatively with other activating marks (e.g., H3K27ac) and serves as a key signature for defining active promoters and enhancers, playing a central regulatory role in processes such as cell differentiation, development, and disease pathogenesis.
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