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Description
BMI-1 Recombinant Rabbit mAb (S-3313-71)Product Specification Host Rabbit Antigen BMI 1 Synonyms Polycomb complex protein BMI 1; Polycomb group RING finger protein 4; RING finger protein 51; PCGF4; RNF51; BMI1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P35226 Clone Number S 3313 71 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample A549, HeLa, U 2 OS, Molt 4 Predicted Reactivity Bv, Ct Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | BMI-1 |
| Synonyms | Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; PCGF4; RNF51; BMI1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P35226 |
| Clone Number | S-3313-71 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | A549, HeLa, U-2 OS, Molt-4 |
| Predicted Reactivity | Bv, Ct |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
BMI-1 (B-cell-specific Moloney murine leukemia virus integration site 1) is a critical polycomb group protein that functions as an essential component of the Polycomb Repressive Complex 1 (PRC1), playing a pivotal role in epigenetic gene silencing by catalyzing the monoubiquitination of histone H2A at lysine 119, thereby repressing key target genes such as the INK4a/ARF locus (which encodes tumor suppressors p16INK4a and p14ARF) to regulate cell cycle progression, cellular senescence, and stem cell self-renewal; beyond its normal physiological functions in development and hematopoiesis, BMI-1 is frequently overexpressed in various malignancies, where it drives tumorigenesis, promotes cancer stem cell maintenance, confers resistance to chemotherapy and radiation, and serves as a significant prognostic marker and potential therapeutic target across numerous cancer types including breast, lung, and colorectal cancers.
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