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Description
CLEC7A His Tag Protein, CynomolgusProduct Specification Species Human Synonyms BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2 Accession A0A2K5UXY6 Amino Acid Sequence Thr 100 Met 281 with His Tag at the N Terminus Expression System HEK293 Molecular Weight 35 40kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size
Product Specification
| Species | Human |
| Synonyms | BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2 |
| Accession | A0A2K5UXY6 |
| Amino Acid Sequence | Thr 100 - Met 281 with His Tag at the N-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 35-40kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive hybridization. Journal of Biological Chemistry, 275(26), 20157-20167. |
Background
The CLEC7A gene in cynomolgus macaque (Macaca fascicularis) encodes a Dectin-1 protein highly homologous to its human counterpart. According to the KEGG pathway database, the cynomolgus macaque CLEC7A gene is designated with the identifier 103218570, and the encoded protein is classified as a C-type lectin receptor family member.
Structural and Functional Homology: As a non-human primate model, cynomolgus macaque Dectin-1 is highly conserved in structure and function with the human protein. It is a type II transmembrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic ITAM motif. This receptor recognizes pathogen-derived β-glucans, activates downstream signaling cascades, induces inflammatory cytokines and chemokines, and triggers innate and adaptive immune responses against pathogens
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