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Description
IGFBP1 Recombinant Rabbit mAb (SDT-196-47)Product Specification Host Rabbit Antigen IGFBP1 Synonyms Insulin like growth factor binding protein 1, IBP 1; IGF binding protein 1, Placental protein 12, PP12 Immunogen Recombinant Protein Location Secreted Accession P08833 Clone Number SDT 196 47 Antibody Type Recombinant mAb Application WB, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,
Product Specification
| Host | Rabbit |
| Antigen | IGFBP1 |
| Synonyms | Insulin-like growth factor-binding protein 1, IBP-1; IGF-binding protein 1, Placental protein 12, PP12 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | P08833 |
| Clone Number | SDT-196-47 |
| Antibody Type | Recombinant mAb |
| Application | WB, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| ICC | 1:250 | null |
Background
Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6 [PMID: 30214426]. IGFBP1, a 40 to 50 kDa protein, which plays an indispensable role in normal growth and development, and in the pathophysiology of various tumors. IGFBP-1 has been shown to be associated with the risk of various tumors, and has a vital function in regulating tumor behaviors such as proliferation, migration, invasion and adhesion through different molecular mechanisms. The biological actions of IGFBP-1 in cancer are found to be related to its phosphorylation state, and the IGF-dependent and -independent mechanisms. [PMID: 1648311, PMID: 33841624].
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