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Description
TMEM16A Recombinant Rabbit mAb (SDT-2179-12)Product Specification Host Rabbit Antigen TMEM16A Synonyms Anoctamin 1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor amplified and overexpressed sequence 2; DOG1; ORAOV2; TAOS2; ANO1 Immunogen Recombinant Protein Location Apical cell membrane Accession Q5XXA6 Clone Number SDT 2179 12 Antibody Type Recombinant mAb Isotype IgG Application IHC P, WB Reactivity Hu
Product Specification
| Host | Rabbit |
| Antigen | TMEM16A |
| Synonyms | Anoctamin-1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2; DOG1; ORAOV2; TAOS2; ANO1 |
| Immunogen | Recombinant Protein |
| Location | Apical cell membrane |
| Accession | Q5XXA6 |
| Clone Number | SDT-2179-12 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
TMEM16A, also known as anoctamin 1, is a multifunctional protein that plays a crucial role in cellular physiology. It functions as a calcium-activated chloride channel, facilitating the transport of chloride ions across cell membranes in response to increases in intracellular calcium levels. This ion channel activity is essential for various physiological processes, including the regulation of membrane potential, cell volume, and the secretion of fluids in epithelial tissues. TMEM16A is widely expressed in different tissues such as the respiratory tract, gastrointestinal tract, and cardiovascular system. Additionally, it has been implicated in the pathogenesis of certain diseases like cystic fibrosis and cancer, making it a potential therapeutic target for the development of new treatments.
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