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Description
DCBLD2 Recombinant Rabbit mAb (S-3292-46)Product Specification Host Rabbit Antigen DCBLD2 Synonyms Discoidin, CUB and LCCL domain containing protein 2; CUB; LCCL and coagulation factor V VIII homology domains protein 1; Endothelial and smooth muscle cell derived neuropilin like protein; CLCP1; ESDN Immunogen Synthetic Peptide Accession Q96PD2 Clone Number S 3292 46 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Mk Positive Sample A549, HCC827, U 2 OS, A375, HT 1080,
Product Specification
| Host | Rabbit |
| Antigen | DCBLD2 |
| Synonyms | Discoidin, CUB and LCCL domain-containing protein 2; CUB; LCCL and coagulation factor V/VIII-homology domains protein 1; Endothelial and smooth muscle cell-derived neuropilin-like protein; CLCP1; ESDN |
| Immunogen | Synthetic Peptide |
| Accession | Q96PD2 |
| Clone Number | S-3292-46 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Mk |
| Positive Sample | A549, HCC827, U-2 OS, A375, HT-1080, PC-3, COS-7 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
Background
DCBLD2 (Discoidin, CUB and LCCL domain-containing protein 2) is a type-I transmembrane scaffolding receptor encoded on chromosome 3q12.1 that contains extracellular CUB, LCCL and coagulation factor V/VIII homology domains, seven conserved intracellular YxxP phosphorylation motifs, and a C-terminal PDZ-binding motif, enabling it to act as a multi-functional platform coupling receptor tyrosine kinases (e.g., EGFR) or non-receptor tyrosine kinases (e.g., Src, Abl) to downstream signaling cascades such as TRAF6-Akt, focal-adhesion/ITGB1-FAK and CRKL pathways, thereby regulating vascular endothelial and smooth-muscle-cell proliferation, angiogenesis, epithelial-to-mesenchymal transition, tumor growth, metastasis and chemo-resistance, while its circulating levels correlate negatively with lung function and its genetic variants can produce multisystem developmental disorders.
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