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Description
Tau (phospho T231) Recombinant Rabbit mAb (SDT-177-1)Product Specification Host Rabbit Antigen Tau (phospho T231) Synonyms p Tau231, phospho T231, Phospho Tau (Thr231) Immunogen Synthetic Peptide Location Cytoplasm, Secreted, Cell membrane Accession P10636 8 Clone Number SDT 177 1 Antibody Type Rabbit mAb Application WB, IP Reactivity Ms Predicted Reactivity Cz, Gor, Pr, Or, Hu, Mq Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | Tau (phospho T231) |
| Synonyms | p-Tau231, phospho T231, Phospho-Tau (Thr231) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Secreted, Cell membrane |
| Accession | P10636-8 |
| Clone Number | SDT-177-1 |
| Antibody Type | Rabbit mAb |
| Application | WB, IP |
| Reactivity | Ms |
| Predicted Reactivity | Cz, Gor, Pr, Or, Hu, Mq |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 |
Background
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites. Tau in healthy neurons carries multiple phosphate groups, mostly in its microtubule assembly domain. Elevated phosphorylation and aggregation of Tau are widely considered pathological hallmarks in Alzheimer's disease (AD) and other tauopathies, triggering the quest for Tau posttranslational modifications in the disease context [PMID: 33892381]. Tau phosphorylation at Thr231 can be detected in cerebrospinal fluid and shows potential as a biomarker of neurofibrillary pathology in Alzheimer’s disease [PMID: 17012293].
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