SKU: 29314404098

Methylfolate - 5 mg, 60 Capsules

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Description

Methylfolate - 5 mg, 60 CapsulesFolate is a vital B vitamin that plays a key role in methylationa critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.* Why Quatrefolic? Quatrefolic is the glucosamine salt of (6S) 5 methyltetrahydrofolatethe

Folate is a vital B vitamin that plays a key role in methylation—a critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic®, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.*

Why Quatrefolic®?

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate—the bioactive form of folate that the body uses directly, without requiring conversion. Unlike folic acid, which must go through multiple enzymatic steps to become active, Quatrefolic® is ready for immediate uptake and use at the cellular level.*

  • Clinically studied for enhanced bioavailability
  • Supports methylation pathways*
  • Supports healthy homocysteine balance*
  • Supports mood and cardiovascular health*
  • Essential for fetal development and reproductive health*

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Who It's For

This high-dose formula is ideal for individuals with increased folate needs or those with MTHFR gene variants who may have trouble converting folic acid to its usable form.*

How It Works

Folate is required to convert homocysteine into methionine—a process vital for cardiovascular and neurological function. It also supports the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which influence mood and cognition.*

What Makes Ours Better?

  • Longevity Focused: We leverage cutting-edge advancements in aging research to formulate products that address the fundamental causes of aging.*
  • Triple Lab Tested: Every product is tested three times by independent 3rd-party labs to ensure we meet the highest standards.
  • Complete Transparency: In an industry flooded with fake supplements, we stand apart by publishing our 3rd-party lab test results. We’re committed to showing you exactly what’s in every bottle, so you can feel confident in what you’re putting into your body. 
  • USA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.
  • 100-Day Risk-Free Guarantee: We stand behind our products. Not satisfied? Reach out to our Santa Barbara, CA office for a full refund within 100 days – no hassle, no questions.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

1 Bani Soheila, J Caring Sci 2013 
2 Mazza A. et al. Biol Regul Homeost Agents 2016
3 Rima Obeid R., Herrmann W. FEBS Letters 580, 2006
4 Stover Patrick, Curr Opin Biotechnol 2017
Seshadri S. at al. N Engl J Med 2002 
6 Bottiglieri T, J Neurol Neurosurg Psychiatry 2000 
7 Thaler C.J. 2014 
8 Stover PJ. Modern Nutrition in Health and Disease 2012
9 Tinelli C, Di Pino A Front. Nutr. 2019

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Folate (as Quatrefolic® (6S)-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 8,500 mcg DFE** (5 mg) 2,125%
* Daily Value (DV) **DFE (Dietary Folate Equivalent) 
REV. 10.24 
  • OTHER INGREDIENTS: Vegetable cellulose (capsule), cellulose.
  • SUGGESTED DAILY USE: Take one (1) capsule daily, or as directed by your healthcare professional.
  • CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18 or are undergoing treatment for a
    medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 29314404098

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4.8 ★★★★★
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Veronica Chung
Massapequa, US
★★★★★ 5
Great Protection w/out the White Cast
Style: SPF 50, Size: 3 Fl Oz (Pack of 1)
We had been using the ThinkBaby mineral sunscreen for years. I wanted to look for a similar alternative but with less white cast. I actually bought this on a whim because it had the fastest shipping at the time (needed it for an outdoor event we were going to). We are now three purchases deep with this product. In my opinion, I think it gives the same amount of sun protection as before without the white cast. It rubs in great. Non-greasy. Initially, the lack of added fragrance was a little off-putting because we were so used to the typical coconut or citrus scents, but we all got used to it. Definitely on my list of subscription purchases now. I wish it was available in a larger size.
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Reviewed in the United States on October 31, 2025
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Verified Purchase
andraloth
San Leandro, US
★★★★★ 5
Smells good, covers well, it does leave a white sheen, I don’t need to reapply.
Style: SPF 50, Size: 3 Fl Oz (Pack of 1)
I use this just once on my face in the morning, apply makeup over it, and I haven’t burned yet! Been using it for two years now. Unfortunate thing is that my face is not tan at all because it doesn’t allow any rays. LOL So I my makeup has to match the rest of my body… I stay under an umbrella at the beach for about half of the time that I’m there. Otherwise I am out in the sun. And I do not reapply this. I am in the sun between the hours of 9 and 1 PM and I’m in and out of the shade and sun half of the time. Still no burning. Actually I don’t think I reapplied it at all once I got home from the beach and I was out at the pool regularly for another hour with no shade. So it seems to be pretty darn good! Some people say they don’t like the smell, but I specifically bought it because I love love love the coconut smell. My daughter says it smells like bananas but I don’t like the smell of bananas and I don’t think it smells like that. It does definitely leave a white sheen. Hence my need for make up.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 20, 2021
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isaaceluna
Alexandria, US
★★★★★ 5
Great for Hawaii!
Style: SPF 50, Size: 3 Fl Oz (Pack of 1)
I spent hours trying to find a sunscreen that was “reef safe” since I was going to be spending a lot of time near corals and this was the best one I found. It doesn’t have any of the 3 ‘O’ ingredients that are known to damage reefs. And the zinc is non nano as well. Sunscreen goes on easily. One of the better mineral sunscreens I’ve tried, this one actually smooths out like lotion and feels hydrating. Only leaves a slight pinkish hue, but that is inevitable with mineral sunscreens (that’s literally how they work in reflecting the sun). I could feel it on even in the ocean so I get protected, but still reapplied almost every 2 hours. No burns! I didn’t use it on my face but my partner did and it never stung his eyes nor caused any breakouts!
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Reviewed in the United States on May 25, 2021
S
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sarah b
Waukegan, US
★★★★★ 4
Stick format is thick and difficult to rub in moderate climates
Style: SPF 50, Size: 1 count (Pack of 1)
I wanted to like it because the small stick format seemed very convenient to keep in my bag for emergency sunscreen reapplication with no chance of leaks. But I think I have learned my lesson about stick sunscreen - in order to hold together in a stick, it has to have a thick and chalky consistency. Which makes it hard to apply and hard to rub in. It's so thick that if I rub the stick over my entire face it feels like I'm applying way too much with a super heavy white cast, and if I dab here and there and try to spread it around, it's so thick it doesn't feel like it spreads into good coverage. The scent is fine. Update: I have found a specific use case for this - in extreme UV conditions like the equatorial tropics in midsummer, it's a good base layer under a more liquid mineral sunscreen, to add extra protection to the most exposed skin, like tops of shoulders, chest, nose and top of forehead. The thickness makes it protect better. It also softens a little and rubs in better in hot temps.
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Reviewed in the United States on October 8, 2025
H
Verified Purchase
hilary
Los Angeles, US
★★★★★ 5
Needs to be warmed, but works great for quick face re-application
Style: SPF 50, Size: 1 count (Pack of 1)
I love mineral sunscreen, it really works the best. But I also do not love mineral sunscreen because it's hard to apply. I don't think it matters what you do, they're just always difficult to apply and always leaving the white. This one isn't much different. I'm a scuba diver and my face sunscreen is washed off quickly doing multiple dives. I also get a weird "mask sunburn" if I don't reapply... but since I'm a diver I can't bring myself to buy or wear sunscreen that's not reef safe into the ocean. I was unsure if this would work because it's pretty solid. I threw it in my bag and once the sun warmed it up a little, I was able to apply it fairly easily between dives. I don't think it works unless it's warmed a bit first, but I like it for this purpose.
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Reviewed in the United States on October 26, 2025

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