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Description
Sinumedin Nasal Spray - 15mlSinumedin, (1. 5 mg + 2. 5 mg) ml, nasal spray, solution Mepyramini maleas + Phenylephrini hydrochloridum Please read this leaflet carefully before taking this medicine because it contains: information important to the patient. Always use this medicine exactly as described in this leaflet or as directed by your doctor or pharmacist. Keep this leaflet so you can read it again if you need to. If you need advice or additional information, please ask your
Sinumedin, (1.5 mg + 2.5 mg)/ml, nasal spray, solution
Mepyramini maleas + Phenylephrini hydrochloridum
Please read this leaflet carefully before taking this medicine because it contains:
information important to the patient.
Always use this medicine exactly as described in this leaflet or as directed by your doctor or pharmacist.
- Keep this leaflet so you can read it again if you need to.
- If you need advice or additional information, please ask your pharmacist.
- If you get any side effects, tell your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See point 4.
- If you do not feel better or if you feel worse after 3 days, contact your doctor.
Table of contents of the leaflet
1. What Sinumedin is and what it is used for
2. Important information before using Sinumedin
3. How to use Sinumedin
4. Possible side effects
5. How to store Sinumedin
6. Package contents and other information
1. What Sinumedin is and what it is used for
Sinumedin contains two active substances: mepyramine maleate and phenylephrine hydrochloride.
Mepyramine has antihistamine and antiallergic properties, and phenylephrine reduces mucosal congestion and clears the nose and openings of the paranasal sinuses.
Additionally, the excipient cetalkonium chloride has antibacterial properties.
Sinumedin relieves a runny nose, clears the nose and the openings of the paranasal sinuses, facilitates breathing and has antibacterial properties.
Sinumedin is indicated for the treatment of:
- rhinitis (rhinitis) in inflammation of the nasal mucosa, including rhinitis occurring in case of
allergies (sensitivities);
- sinusitis.
2. Important information before using Sinumedin
When not to use Sinumedin
- if you are allergic to the active substances or any of the other ingredients of the medicine (listed in section 6);
- in children under 6 years of age;
- during pregnancy and breastfeeding.
Warnings and precautions
Talk to your doctor or pharmacist before taking Sinumedin:
- if you are a child;
- if you are elderly;
- if you suffer from allergic diseases (e.g. asthma) or dry rhinitis;
- if you have heart failure;
- if you have high blood pressure;
- if you have diabetes;
- if you have pheochromocytoma;
- if you have hyperthyroidism;
- if you have an enlarged prostate gland;
- if you have narrow angle glaucoma;
- if you have been taking medicines to treat depression called monoamine oxidase inhibitors (selegiline, moclobemide, amiflamine), you should only use Sinumedin at least 14 days after stopping treatment with these medicines, unless your doctor tells you otherwise.
Kids
Do not use in children under 6 years of age.
Sinumedin and other medicines
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
If you are taking any of the medicines listed below, you may need to change them
dose or discontinuation of treatment:
- barbiturates, hypnotics and sedatives, atropine, tricyclic antidepressants (imipramine, opipramol, amitriptyline, doxepin, mianserin) - Sinumedin may intensify their effect;
- some beta-blockers, such as esmolol, may increase the effect of the phenylephrine component of Sinumedin, which may result in severe hypertension in some patients;
- monoamine oxidase inhibitors such as selegiline, moclobemide, amiflamine prolong and intensify the effect of Sinumedin.
Sinumedin with food, drink and alcohol
Sinumedin can be taken regardless of food or drink.
Sinumedin may enhance the effects of alcohol.
Pregnancy and breastfeeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to be pregnant
child, ask your doctor for advice before taking this medicine.
Sinumedin must not be used during pregnancy and breastfeeding.
Driving and using machines
Sinumedin has minor or moderate influence on the ability to drive and use machines. Be careful.
Sinumedin contains methyl parahydroxybenzoate and propyl parahydroxybenzoate
The medicine may cause allergic reactions (possibly delayed reactions). The drug may cause minor irritation to the skin, eyes and mucous membranes.
3. How to use Sinumedin
Always use this medicine exactly as described in this leaflet or as directed by your doctor or pharmacist. If in doubt, ask your doctor or pharmacist.
The drug is administered intranasally.
The recommended dose is
adults and children over 6 years old:
2 doses in each nasal passage every 4 to 6 hours.
A single spray dose contains 0.15 mg of mepyramine maleinate and 0.25 mg of phenylephrine hydrochloride.
Do not use the medicine more than 5 times a day or for longer than 3 days.
If you take more Sinumedin than you should
If you use more than the recommended dose, contact your doctor.
In case of overdose, the following may occasionally occur: headaches and dizziness, sleep disturbances, difficulty urinating, heart rhythm disturbances.
If you forget to take Sinumedin
Do not take a double dose to make up for a missed dose.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
The following are the side effects that may occur when using Sinumedin:
- tachycardia, palpitations, arrhythmia;
- headache, dizziness, drowsiness, sedation, insomnia, weakness;
- diarrhea, nausea, constipation;
hypertension;
- irritation and congestion of the nasal mucosa, dryness of the mucous membranes.
Reporting side effects
If you notice any side effects, including any side effects
not listed in this leaflet, please tell your doctor or pharmacist.
Adverse reactions can be reported directly to the Monitoring Department
Adverse Effects of Medicinal Products of the Office for Registration of Medicinal Products,
Medical Devices, Biocidal Products
Al. Jerozolimskie 181C, 02-222 Warszawa
tel.: + 48 22 49 21 301
fax: + 48 22 49 21 309
e-mail: [email protected]
Side effects can also be reported to the responsible entity.
By reporting side effects, more information can be gathered
about the safety of using the drug.
5. How to store Sinumedin
Keep the medicine out of the sight and reach of children. Store at temperatures below 25°C.
Do not use this medicine after the expiry date which is stated on the package. The expiry date means the last day of the given month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines you no longer use. Such behavior will help to protect the environment.
6. Package contents and other information
What Sinumedin contains
- The active substances are: mepyramine maleate and phenylephrine hydrochloride.
1 ml of nasal spray contains 1.5 mg of mepyramine maleate and 2.5 mg of phenylephrine hydrochloride.
- The other ingredients are: glycerol, sodium chloride, cetalkonium chloride, methyl parahydroxybenzoate, propyl parahydroxybenzoate, polysorbate 20, purified water.
What Sinumedin looks like and what the pack contains
Sinumedin is a nasal spray.
The spray bottle contains 10 ml, 15 ml or 20 ml of medicine in a cardboard box.
Responsible entity and manufacturer
Aflofarm Farmacja Polska Sp. z o. o.
Partyzancka 133/151
95-200 Pabianice
tel. (42) 22-53-100
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
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- Delivery to the USA:
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.6 ★★★★★
Based on 21 reviews
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Product Reviews
★★★★★ 4
Comfortable and Stylish Shoes
Size: 8.5, Color: British Tan/Ivory
These shoes are very comfortable and stylish. The quality feels great, and they fit perfectly. I can wear them for a long time without discomfort. They look elegant with both casual and dress clothes. Definitely worth the price and I would recommend them to others. ⭐⭐⭐⭐⭐
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Reviewed in the United States on May 8, 2026
★★★★★ 5
Great Shoe
Size: 10.5 Wide, Color: Black Leather/Black
Great shoe! Especially for those that are on the move in a professional setting for a lot of the day. The only issue I’ve had with these so far are my shoe laces are warping. The shoe itself is holding up great.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 11, 2026
★★★★★ 5
A great purchase
Size: 10.5, Color: British Tan/Ivory
These shoes are very comfortable and attractive. Lots of people noticed them when I first wore them. I would not consider them the most dressy shoes you can buy, but they work for "business casual" and most other outfits (but not shorts).
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 24, 2026
★★★★★ 4
All-Day Comfort for 10+ Hour Workdays. Finally Found a Pair That Holds Up
Size: 12, Color: Black Leather/Black, Size: 12, Color: Black Leather/Black
After years of trying different “comfortable” dress shoes, this is the first pair I’ve owned that I can wear for a full 10+ hour workday without counting down the minutes to take them off.
For context, I’m a retail district manager. I’m on my feet most of the day walking stores, standing in conversations, moving constantly. I’ve owned Clarks, Rockport, and even higher-end dress shoes, and while some started out comfortable, none of them held up for an entire day without foot fatigue setting in.
These Cole Haan shoes are different.
What stands out:
All-day comfort: No mid-day foot pain, even after long shifts.
Solid construction: Genuine leather that takes and holds a polish well.
Supportive sole: Noticeably helps with impact from constant walking.
Great value: Performs better than shoes I’ve paid significantly more for.
I also appreciate that they hit a nice middle ground stylistically; more business casual than formal, but still sharp enough for most professional environments.
For additional context, I am a heavier individual and tend to wear down the outer (lateral) edge of my shoes first. That pattern holds true here as well.
The only drawback:
After about two months of wearing them 5 days a week (purchased January 7th), the sole shows more wear than I would expect at this point. It’s not a dealbreaker, but it’s the reason I’m giving 4 stars instead of 5. I’ll be including a comparison photo between the worn pair and a new pair for reference.
That said, I still expect to get around 8–10 months of use out of them, which at this price point is more than fair.
Bottom line:
If you need a comfortable, reliable, and reasonably priced work shoe for long days on your feet, these outperform just about everything else I’ve tried, and that’s why I bought a second pair.
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Reviewed in the United States on March 24, 2026
★★★★★ 5
Great Shoes
Size: 10, Color: Cognac
Love these shoes super comfortable and look great. Everyone asks me where I got them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 20, 2026